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DNA methylation profiling of normal prostates and prostate cancer metastases [Illumina]

ABSTRACT: DNA methylation profiling of normal prostates from organ donors and prostate cancer metastases from a rapid autopsy cohort of lethal metastatic prostate cancer Metastases from prostate cancer patients. Normal prostate samples from organ donors

ORGANISM(S): Homo sapiens

SUBMITTER: Martin Aryee

PROVIDER: E-GEOD-38240 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases.

Aryee Martin J MJ Liu Wennuan W Engelmann Julia C JC Nuhn Philipp P Gurel Meltem M Haffner Michael C MC Esopi David D Irizarry Rafael A RA Getzenberg Robert H RH Nelson William G WG Luo Jun J Xu Jianfeng J Isaacs William B WB Bova G Steven GS Yegnasubramanian Srinivasan S

Science translational medicine 20130101 169

Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations in epigenetic marks, including DNA methylation, are potentially heritable, they can also be dynamically altered. Given this potential for plasticity, the degree to which epigenetic changes can be subject to selection and act as drivers of neoplasia has been questioned. We carried out genome-scale analyses of DNA methylation alterations in lethal metastatic prostate cancer and created DNA methylation "citys ...[more]

PMID: 23345608

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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