Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ramón García-Escudero
PROVIDER: E-GEOD-38257 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Costa Clotilde C Santos Mirentxu M Segrelles Carmen C Dueñas Marta M Lara M Fernanda MF Agirre Xabier X Prosper Felipe F García-Escudero Ramón R Paramio Jesús M JM
Scientific reports 20121109
The specific ablation of Rb1 gene in stratified epithelia (Rb(F/F);K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the functions of pRb in these tissues; however, Rb(F/F);K14cre;p107(-/-) mice die postnatally. Here we show, using an inducible mouse model (Rb(F/F);K14creER(TM)), that p107 exerts specific tumor suppressor functions in the absence of pRb in stratified epithelia. The simultaneou ...[more]