Unknown,Transcriptomics,Genomics,Proteomics

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Functional analysis of ABCB5 in melanoma cells


ABSTRACT: Functional analysis of ABCB5 in A375 and G3361 melanoma cells, by comparing stably-transfected controls to ABCB5-shRNA-targeted cells. 12 samples total. Replicates n=3 for the following 4 groups: A375 pSUPER-retro-puro-Vector vs. A375 pSUPER-retro-puro-ABCB5-KD; G3361 pSUPER-retro-puro-shCNTRL vs. G3361 pSUPER-retro-puro-ABCB5-KD.

ORGANISM(S): Homo sapiens

SUBMITTER: Markus Frank 

PROVIDER: E-GEOD-38290 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit.

Wilson Brian J BJ   Saab Karim R KR   Ma Jie J   Schatton Tobias T   Pütz Pablo P   Zhan Qian Q   Murphy George F GF   Gasser Martin M   Waaga-Gasser Ana Maria AM   Frank Natasha Y NY   Frank Markus H MH  

Cancer research 20140616 15


The drug efflux transporter ABCB5 identifies cancer stem-like cells (CSC) in diverse human malignancies, where its expression is associated with clinical disease progression and tumor recurrence. ABCB5 confers therapeutic resistance, but other functions in tumorigenesis independent of drug efflux have not been described that might help explain why it is so broadly overexpressed in human cancer. Here we show that in melanoma-initiating cells, ABCB5 controls IL1β secretion, which serves to maintai  ...[more]

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