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Metabolic responses of the model archaeon Halobacterium sp. NRC-1 to oxygen limitation


ABSTRACT: As part of a comprehensive post-genomic investigation of the model archaeon Halobacterium sp. NRC-1, we used whole genome DNA microarrays to compare transcriptional profiles of cells grown anaerobically via arginine fermentation versus cells either respiring aerobically in the presence of oxygen or anaerobically using trimethylamine N-oxide (TMAO) as a terminal electron acceptor. In the study presented here, a consecutively performed series of experiments were performed to examine the effects of regulator deletions (dmsR, bat) and oxygen limitations of Haloarchaeal cells. Microarrays were used to acquire expression profiles of a total of 2484 genes, leading to the successful identification of affected genes.

ORGANISM(S): Halobacterium sp. NRC-1

SUBMITTER: Priya DasSarma 

PROVIDER: E-GEOD-38374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide responses of the model archaeon Halobacterium sp. strain NRC-1 to oxygen limitation.

DasSarma Priya P   Zamora Regie C RC   Müller Jochen A JA   DasSarma Shiladitya S  

Journal of bacteriology 20120803 20


As part of a comprehensive postgenomic investigation of the model archaeon Halobacterium sp. strain NRC-1, we used whole-genome DNA microarrays to compare transcriptional profiles of cells grown under anaerobic or aerobic conditions. When anaerobic growth supported by arginine fermentation was compared to aerobic growth, genes for arginine fermentation (arc) and anaerobic respiration (dms), using trimethylamine N-oxide (TMAO) as the terminal electron acceptor, were highly upregulated, as was the  ...[more]

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