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Global DNA methylation study of trisomy 8 AML

ABSTRACT: We report the application of methylated DNA immunoprecipitation followed by next-generation sequencing to trisomy 8 AML. Through a global study and quantifying the methylation signals, we demonstrated a characteristic DNA methylation distribution for trisomy 8 indicating the impact of the hypermethylation of the extrachromosome 8 on suppressing the signals on the rest of the chromosomes. Examination of 3 relapse trisomy 8 AML patients

ORGANISM(S): Homo sapiens

SUBMITTER: Jacek Marzec

PROVIDER: E-GEOD-38483 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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