Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ling-Ling Chen
PROVIDER: E-GEOD-38541 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yin Qing-Fei QF Yang Li L Zhang Yang Y Xiang Jian-Feng JF Wu Yue-Wei YW Carmichael Gordon G GG Chen Ling-Ling LL
Molecular cell 20120906 2
We describe the discovery of sno-lncRNAs, a class of nuclear-enriched intron-derived long noncoding RNAs (lncRNAs) that are processed on both ends by the snoRNA machinery. During exonucleolytic trimming, the sequences between the snoRNAs are not degraded, leading to the accumulation of lncRNAs flanked by snoRNA sequences but lacking 5' caps and 3' poly(A) tails. Such RNAs are widely expressed in cells and tissues and can be produced by either box C/D or box H/ACA snoRNAs. Importantly, the genomi ...[more]