Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Chuan Wang
PROVIDER: E-GEOD-38567 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Chuan C Sandling Johanna K JK Hagberg Niklas N Berggren Olof O Sigurdsson Snaevar S Karlberg Olof O Rönnblom Lars L Eloranta Maija-Leena ML Syvänen Ann-Christine AC
Annals of the rheumatic diseases 20120623 1
<h4>Background</h4>The transcription factors interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are encoded by two of the strongest susceptibility genes for systemic lupus erythematosus (SLE).<h4>Objective</h4>To investigate the target genes and functional roles of IRF5 and STAT4 in human peripheral blood mononuclear cells (PBMCs).<h4>Methods</h4>Chromatin immunoprecipitation-sequencing (ChIP-seq) was performed in PBMCs stimulated to activate IRF ...[more]