Ontology highlight
ABSTRACT:
ORGANISM(S): Pan troglodytes
SUBMITTER: Darren Cusanovich
PROVIDER: E-GEOD-38572 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Iskow Rebecca C RC Gokcumen Omer O Abyzov Alexej A Malukiewicz Joanna J Zhu Qihui Q Sukumar Ann T AT Pai Athma A AA Mills Ryan E RE Habegger Lukas L Cusanovich Darren A DA Rubel Meagan A MA Perry George H GH Gerstein Mark M Stone Anne C AC Gilad Yoav Y Lee Charles C
Proceedings of the National Academy of Sciences of the United States of America 20120713 31
Gene expression differences are shaped by selective pressures and contribute to phenotypic differences between species. We identified 964 copy number differences (CNDs) of conserved sequences across three primate species and examined their potential effects on gene expression profiles. Samples with copy number different genes had significantly different expression than samples with neutral copy number. Genes encoding regulatory molecules differed in copy number and were associated with significa ...[more]