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Genome-wide analysis of mRNA expression alterations of sorted LysM-KI LSK cells versus control LSK cells

ABSTRACT: Microarrays were used to examine gene expression changes between bone marrow isolated haematopoeietic cell populations (LSK cells: Lin-Sca1+cKit+) populations of control and mutant (LysM-KI) mice. The LysM-KI mouse is a murine model which expresses an Idh1 (isocitrate dehydrogenase 1) mutation (Idh1-R132H) in cells of the myeloid lineage. Mutations in IDH1 (and IDH2) in humans are commonly found in cytogenetically normal acute myeloid leukemia as well as glioblastomas. The current study was initiated to understand how these mutations may affect leukemogenesis and myeloid cell development. Total RNA obtained from bone marrow sorted LSK cells of mutant LysM-KI and control individual mice.

ORGANISM(S): Mus musculus

SUBMITTER: carl virtanen 

PROVIDER: E-GEOD-38589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequently found in human glioblastomas and cytogenetically normal acute myeloid leukaemias (AML). These alterations are gain-of-function mutations in that they drive the synthesis of the ‘oncometabolite’ R-2-hydroxyglutarate (2HG). It remains unclear how IDH1 and IDH2 mutations modify myeloid cell development and promote leukaemogenesis. Here we report the characterization of conditional knock-in (KI) mice in which the  ...[more]

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