Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from primary tissue, human oral mucosa (mRNA data)

ABSTRACT: The experiment aims to identify regulatory miRNA networks influencing mRNA profiles in oral lichen planus (OLP). RNA and miRNA were extracted simultaneously using miRVana (Ambion, Life Technologies). Sample and array processing was carried out according to the manufacturer's guidelines. Affymetrix raw data was processed using AGCC Expression Console 1.1 (Affymetrix), employing RMA normalization. Linking miRNA and mRNA was performed with a correlation analysis, while a false discovery rate was used to exclude false-positive correlations between miRNAs and their predicted targets. 7 cases (OLP) and 7 controls (healthy individuals). Genome wide mRNA and miRNA screening, linking both datasets (see summary).

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Häsler 

PROVIDER: E-GEOD-38616 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Disease-associated miRNA-mRNA networks in oral lichen planus.

Gassling Volker V   Hampe Jochen J   Açil Yahya Y   Braesen Jan Hinrich JH   Wiltfang Jörg J   Häsler Robert R  

PloS one 20130527 5

<h4>Background</h4>A large number of pathophysiological mechanisms are regulated by microRNAs (miRNAs), which represent a new class of posttranscriptional regulators of gene expression. To date, little is known about their role in oral lichen planus (OLP), a chronic inflammatory mucocutaneous disease of unknown etiology which is being discussed as a potentially premalignant condition of oropharyngeal cancer. The aim of the present investigation was to assess the pathophysiological impact of miRN  ...[more]

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