Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE38622: Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [telogen]. GSE38623: Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [Anagen] GSE38624: Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [Bmal1 KO] Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: mikhail geyfman 

PROVIDER: E-GEOD-38625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis.

Geyfman Mikhail M   Kumar Vivek V   Liu Qiang Q   Ruiz Rolando R   Gordon William W   Espitia Francisco F   Cam Eric E   Millar Sarah E SE   Smyth Padhraic P   Ihler Alexander A   Takahashi Joseph S JS   Andersen Bogi B  

Proceedings of the National Academy of Sciences of the United States of America 20120702 29


The role of the circadian clock in skin and the identity of genes participating in its chronobiology remain largely unknown, leading us to define the circadian transcriptome of mouse skin at two different stages of the hair cycle, telogen and anagen. The circadian transcriptomes of telogen and anagen skin are largely distinct, with the former dominated by genes involved in cell proliferation and metabolism. The expression of many metabolic genes is antiphasic to cell cycle-related genes, the for  ...[more]

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