Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Elisabeth Israelsson
PROVIDER: E-GEOD-38652 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Herman Melina M Ciancanelli Michael M Ou Yi-Hung YH Lorenzo Lazaro L Klaudel-Dreszler Maja M Pauwels Elodie E Sancho-Shimizu Vanessa V Pérez de Diego Rebeca R Abhyankar Avinash A Israelsson Elisabeth E Guo Yiqi Y Cardon Annabelle A Rozenberg Flore F Lebon Pierre P Tardieu Marc M Heropolitanska-Pliszka Edyta E Chaussabel Damien D White Michael A MA Abel Laurent L Zhang Shen-Ying SY Casanova Jean-Laurent JL
The Journal of experimental medicine 20120730 9
Childhood herpes simplex virus-1 (HSV-1) encephalitis (HSE) may result from single-gene inborn errors of TLR3 immunity. TLR3-dependent induction of IFN-α/β or IFN-λ is crucial for protective immunity against primary HSV-1 infection in the central nervous system (CNS). We describe here two unrelated children with HSE carrying different heterozygous mutations (D50A and G159A) in TBK1, the gene encoding TANK-binding kinase 1, a kinase at the crossroads of multiple IFN-inducing signaling pathways. B ...[more]