Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Marion Horsch
PROVIDER: E-GEOD-38737 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ju Limei L Wing Jonathan J Taylor Elaine E Brandt Renata R Slijepcevic Predrag P Horsch Marion M Rathkolb Birgit B Rácz Ildikó I Becker Lore L Hans Wolfgang W Adler Thure T Beckers Johannes J Rozman Jan J Klingenspor Martin M Wolf Eckhard E Zimmer Andreas A Klopstock Thomas T Busch Dirk H DH Gailus-Durner Valérie V Fuchs Helmut H de Angelis Martin Hrabě MH van der Horst Gilbertus G Lehmann Alan R AR
DNA repair 20130318 5
Smc5-6 is a highly conserved protein complex related to cohesin and condensin involved in the structural maintenance of chromosomes. In yeasts the Smc5-6 complex is essential for proliferation and is involved in DNA repair and homologous recombination. siRNA depletion of genes involved in the Smc5-6 complex in cultured mammalian cells results in sensitivity to some DNA damaging agents. In order to gain further insight into its role in mammals we have generated mice mutated in the Smc6 gene. A co ...[more]