Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Differential regulation of microRNAs in skeletal muscle from monozygotic twins discordant for type 2 diabetes

ABSTRACT: Analysis of microRNA expression in vastus lateralis muscle biopsies from 11 genetically identical twin pairs discordant for type 2 diabetes. This eliminates the influence of genotype and leads to the identification of microRNAs that are exclusively influenced by environmental (non-genetic) factors. Total RNA containing microRNAs were obtained from muscle biopsies (vastus lateralis) from genetically identical twin pairs (n=11 pairs). All twin pairs were discordant in respect to their glucose tolerance; thus, one twin has diabetes whereas the co-twin has either normal or impaired glucose tolerance.

ORGANISM(S): Homo sapiens

SUBMITTER: jette bork-jensen 

PROVIDER: E-GEOD-38835 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

<h4>Aims/hypothesis</h4>We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of developing the disease in skeletal muscle biopsies from phenotypically well-characterised twins.<h4>Methods</h4>We measured muscle miRNA levels in monozygotic (MZ) twins discordant for type 2 diabetes using arrays. Further investigations of selected miRNAs included target prediction, pathway analysis, silencing in cells and association analyses in a separate cohort of 164 non-diabetic MZ a  ...[more]

Similar Datasets

Genomics Differential regulation of microRNAs in skeletal muscle from monozygotic twins discordant for type 2 diabetes
2014-11-19 | GSE38835 | GEO
Transcriptomics Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy
2011-01-01 | E-GEOD-21421 | biostudies-arrayexpress
Methylation profiling Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes
2012-12-10 | GSE38291 | GEO
Transcriptomics Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes
2012-12-10 | E-GEOD-38291 | biostudies-arrayexpress
Genomics Hypermethylation in the ZBTB20 gene is associated with major depressive disorder
2014-01-25 | E-GEOD-54370 | biostudies-arrayexpress
Transcriptomics Epigenome analysis of male identical twin pairs discordant for sexual orientation, age 21 to 55.
2011-04-21 | E-GEOD-28746 | biostudies-arrayexpress
Transcriptomics Transcriptome Analysis of Human Supragingival Dental Plaque Microbiome from 19 Twin Pairs with and without Dental Caries
2011-09-26 | GSE31439 | GEO
Methylation profiling Genome-wide DNA methylation analysis in peripheral blood of monozygotic twins informative for psychopathology
2018-09-22 | GSE120307 | GEO
Transcriptomics MHO Twin Study
2013-10-16 | E-MTAB-1895 | biostudies-arrayexpress
Transcriptomics Investigation of somatic copy number variation in MZ twins
2010-12-11 | E-GEOD-25826 | biostudies-arrayexpress