Gene expression networks in COPD: microRNA and mRNA regulation
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ji-Hoon Cho
PROVIDER: E-GEOD-38974 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression networks in COPD: microRNA and mRNA regulation.
Ezzie Michael E ME Crawford Melissa M Cho Ji-Hoon JH Orellana Robert R Zhang Shile S Gelinas Richard R Batte Kara K Yu Lianbo L Nuovo Gerard G Galas David D Diaz Philip P Wang Kai K Nana-Sinkam S Patrick SP
Thorax 20110922 2
<h4>Background</h4>The mechanisms underlying chronic obstructive pulmonary disease (COPD) remain unclear. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that modulate the levels of specific genes and proteins. Identifying expression patterns of miRNAs in COPD may enhance our understanding of the mechanisms of disease. A study was undertaken to determine if miRNAs are differentially expressed in the lungs of smokers with and without COPD. miRNA and mRNA expression were compared to ...[more]
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