Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Pere Puigserver
PROVIDER: E-GEOD-39009 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blättler Sharon M SM Verdeguer Francisco F Liesa Marc M Cunningham John T JT Vogel Rutger O RO Chim Helen H Liu Huifei H Romanino Klaas K Shirihai Orian S OS Vazquez Francisca F Rüegg Markus A MA Shi Yang Y Puigserver Pere P
Molecular and cellular biology 20120618 16
The formation, distribution, and maintenance of functional mitochondria are achieved through dynamic processes that depend strictly on the transcription of nuclear genes encoding mitochondrial proteins. A large number of these mitochondrial genes contain binding sites for the transcription factor Yin Yang 1 (YY1) in their proximal promoters, but the physiological relevance is unknown. We report here that skeletal-muscle-specific YY1 knockout (YY1mKO) mice have severely defective mitochondrial mo ...[more]