Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from mouse skeletal muscle


ABSTRACT: We generated skeletal muscle-specific knockout mice lacking the transcription factor Yin Yang 1 (YY1) and analyzed expression patterns in the skeletal muscle these mice. We used microarrays to detail the global programme of gene expression regulated by YY1. Wild type or knockout mice at 6 months were sacrificed and the soleus was isolated for RNA extraction.

ORGANISM(S): Mus musculus

SUBMITTER: Pere Puigserver 

PROVIDER: E-GEOD-39009 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle.

Blättler Sharon M SM   Verdeguer Francisco F   Liesa Marc M   Cunningham John T JT   Vogel Rutger O RO   Chim Helen H   Liu Huifei H   Romanino Klaas K   Shirihai Orian S OS   Vazquez Francisca F   Rüegg Markus A MA   Shi Yang Y   Puigserver Pere P  

Molecular and cellular biology 20120618 16


The formation, distribution, and maintenance of functional mitochondria are achieved through dynamic processes that depend strictly on the transcription of nuclear genes encoding mitochondrial proteins. A large number of these mitochondrial genes contain binding sites for the transcription factor Yin Yang 1 (YY1) in their proximal promoters, but the physiological relevance is unknown. We report here that skeletal-muscle-specific YY1 knockout (YY1mKO) mice have severely defective mitochondrial mo  ...[more]

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