Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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RNA-Seq and expression data from human adipose tissue


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Yichuan Liu 

PROVIDER: E-GEOD-39118 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

PennSeq: accurate isoform-specific gene expression quantification in RNA-Seq by modeling non-uniform read distribution.

Hu Yu Y   Liu Yichuan Y   Mao Xianyun X   Jia Cheng C   Ferguson Jane F JF   Xue Chenyi C   Reilly Muredach P MP   Li Hongzhe H   Li Mingyao M  

Nucleic acids research 20131220 3


Correctly estimating isoform-specific gene expression is important for understanding complicated biological mechanisms and for mapping disease susceptibility genes. However, estimating isoform-specific gene expression is challenging because various biases present in RNA-Seq (RNA sequencing) data complicate the analysis, and if not appropriately corrected, can affect isoform expression estimation and downstream analysis. In this article, we present PennSeq, a statistical method that allows each i  ...[more]

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