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Transcript profiling of Lin-Sca-1+c-Kit+ (LSK) cells from mice reconstituted with wild type and necdin null fetal liver cells following a sublethal dose of irradiation (6,5 Gy)

ABSTRACT: compare the gene expression profile between irradiated Lin-Sca-1+c-Kit+ (LSK) cells from mouse bone marrow reconstituted with wild type and necdin null fetal liver cells The Affymetrix oligonucleotide array was used for this analysis compare the gene expression profile betweenirradiated Lin-Sca-1+c-Kit+ (LSK) cells from mouse bone marrow reconstituted with wild type and necdin null fetal liver cells

ORGANISM(S): Mus musculus

SUBMITTER: Jeffrey Zhao 

PROVIDER: E-GEOD-39153 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.

Asai Takashi T   Liu Yan Y   Di Giandomenico Silvana S   Bae Narae N   Ndiaye-Lobry Delphine D   Deblasio Anthony A   Menendez Silvia S   Antipin Yevgeniy Y   Reva Boris B   Wevrick Rachel R   Nimer Stephen D SD  

Blood 20120709 8

We recently defined a critical role for p53 in regulating the quiescence of adult hematopoietic stem cells (HSCs) and identified necdin as a candidate p53 target gene. Necdin is a growth-suppressing protein and the gene encoding it is one of several that are deleted in patients with Prader-Willi syndrome. To define the intrinsic role of necdin in adult hematopoiesis, in the present study, we transplanted necdin-null fetal liver cells into lethally irradiated recipients. We show that necdin-null  ...[more]

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