Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis thaliana
SUBMITTER: Christopher Hale
PROVIDER: E-GEOD-39247 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhong Xuehua X Hale Christopher J CJ Law Julie A JA Johnson Lianna M LM Feng Suhua S Tu Andy A Jacobsen Steven E SE
Nature structural & molecular biology 20120805 9
The plant-specific DNA-dependent RNA polymerase V (Pol V) evolved from Pol II to function in an RNA-directed DNA methylation pathway. Here, we have identified targets of Pol V in Arabidopsis thaliana on a genome-wide scale using ChIP-seq of NRPE1, the largest catalytic subunit of Pol V. We found that Pol V is enriched at promoters and evolutionarily recent transposons. This localization pattern is highly correlated with Pol V-dependent DNA methylation and small RNA accumulation. We also show tha ...[more]