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Comparative transcriptome analyses of deltmethrin resistant and suscpetible Anopheles gambiae mosquitoes

ABSTRACT: we report the RNA-seq based analyses of the transcriptional changes in the Anopheles gambiae mosquitoes from East Africa classified as deltamethrin-resistant or -suscpetible accordign the WHO test comparison of the transcriptome of Anopheles gambiae mosquitoes with phenotypically resistant or suscpetible to deltamethrin

ORGANISM(S): Anopheles gambiae

SUBMITTER: Mariangela Bonizzoni 

PROVIDER: E-GEOD-39269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparative transcriptome analyses of deltamethrin-resistant and -susceptible Anopheles gambiae mosquitoes from Kenya by RNA-Seq.

Bonizzoni Mariangela M   Afrane Yaw Y   Dunn William Augustine WA   Atieli Francis K FK   Zhou Goufa G   Zhong Daibin D   Li Jun J   Githeko Andrew A   Yan Guiyun G  

PloS one 20120907 9

Malaria causes more than 300 million clinical cases and 665,000 deaths each year, and the majority of the mortality and morbidity occurs in sub-Saharan Africa. Due to the lack of effective vaccines and wide-spread resistance to antimalarial drugs, mosquito control is the primary method of malaria prevention and control. Currently, malaria vector control relies on the use of insecticides, primarily pyrethroids. The extensive use of insecticides has imposed strong selection pressures for resistanc  ...[more]

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