Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Tobias Österlund
PROVIDER: E-GEOD-39311 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hou Jin J Tang Hongting H Liu Zihe Z Österlund Tobias T Nielsen Jens J Petranovic Dina D
FEMS yeast research 20131212 3
In yeast Saccharomyces cerevisiae, accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR), which is mediated by Hac1p. The heat shock response (HSR) mediated by Hsf1p, mainly regulates cytosolic processes and protects the cell from stresses. Here, we find that a constitutive activation of the HSR could increase ER stress resistance in both wild-type and UPR-deficient cells. Activation of HSR decreased UPR activation ...[more]