Transcriptomes of K562 cell line
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: yadong yang
PROVIDER: E-GEOD-39374 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dynamic transcriptomes of human myeloid leukemia cells.
Wang Hai H Hu Haiyan H Zhang Qian Q Yang Yadong Y Li Yanming Y Hu Yang Y Ruan Xiuyan X Yang Yaran Y Zhang Zhaojun Z Shu Chang C Yan Jiangwei J Wakeland Edward K EK Li Quanzhen Q Hu Songnian S Fang Xiangdong X
Genomics 20130624 4
To identify the mechanisms controlling chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) in humans, we analyzed genome-wide transcription dynamics in three myeloid leukemia cell lines (K562, HL-60, and THP1) using high-throughput sequencing technology. Using KEGG analysis, we found that the ERK/MAPK, JAK-STAT and ErbB pathways promoted proliferation and metabolism in CML. However, in AML, differentiation and apoptosis blocking resulted in the accumulation of blast cells in marrow. ...[more]
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