Role of PRC2 complex components in prostate cancer cell lines
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kexin Xu
PROVIDER: E-GEOD-39461 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.
Xu Kexin K Wu Zhenhua Jeremy ZJ Groner Anna C AC He Housheng Hansen HH Cai Changmeng C Lis Rosina T RT Wu Xiaoqiu X Stack Edward C EC Loda Massimo M Liu Tao T Xu Han H Cato Laura L Thornton James E JE Gregory Richard I RI Morrissey Colm C Vessella Robert L RL Montironi Rodolfo R Magi-Galluzzi Cristina C Kantoff Philip W PW Balk Steven P SP Liu X Shirley XS Brown Myles M
Science (New York, N.Y.) 20121201 6113
Epigenetic regulators represent a promising new class of therapeutic targets for cancer. Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2), silences gene expression via its histone methyltransferase activity. We found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independent of its role as a transcriptional repressor. Instead, it involves the ability of EZH2 to act as a coactivator for critical transcription factors in ...[more]
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