Unknown,Transcriptomics,Genomics,Proteomics

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Identification of gonadotropin-responsive genes in fish testis


ABSTRACT: In all vertebrates, the dual function of testis (production of sexual steroids and production of gametes) is mainly regulated by two gonadotropic pituitary hormones, FSH and LH. However, in fish the biological activities of the two hormones are not still clearly delineated and moreover, their molecular mechanisms are yet poorly understood. In this study we investigated the effects of FSH and LH on testicular gene expression, in the rainbow trout, at two developmental stages I-II and III (I: spermatogonia only, II: active spermatogonia proliferation, III: meiosis onset with the appearance of spermatocytes and round spermatids). Testes were collected from all-male population rainbow trout and incubated in six replicates for 96 hours, at 12°C, in the absence or presence of purified salmonid gonadotropins, FSH and LH (500 ng/mL).

ORGANISM(S): Oncorhynchus mykiss

SUBMITTER: Elisabeth Sambroni 

PROVIDER: E-GEOD-39465 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

FSH and LH have common and distinct effects on gene expression in rainbow trout testis.

Sambroni Elisabeth E   Rolland Antoine D AD   Lareyre Jean-Jacques JJ   Le Gac Florence F  

Journal of molecular endocrinology 20121231 1


The general rules established from mammalian species for the regulation of spermatogenesis by gonadotropins may not be fully relevant in fish. Particularly, Fsh is as potent as Lh to stimulate steroidogenesis and the Fsh receptor is expressed in Leydig cells. In seasonal breeders, Fsh is likely the major gonadotropin involved in spermatogenesis onset and Lh is required to support spermatogenesis progression and gamete release. However, the genes that relay the action of Fsh and Lh have been poor  ...[more]

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