Ontology highlight
ABSTRACT:
ORGANISM(S): Chlamydia trachomatis
SUBMITTER: Dan Sturdevant
PROVIDER: E-GEOD-39530 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Omsland Anders A Sager Janet J Nair Vinod V Sturdevant Daniel E DE Hackstadt Ted T
Proceedings of the National Academy of Sciences of the United States of America 20121105 48
Chlamydia trachomatis is among the most clinically significant human pathogens, yet their obligate intracellular nature places severe restrictions upon research. Chlamydiae undergo a biphasic developmental cycle characterized by an infectious cell type known as an elementary body (EB) and an intracellular replicative form called a reticulate body (RB). EBs have historically been described as metabolically dormant. A cell-free (axenic) culture system was developed, which showed high levels of met ...[more]