Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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C.elegans exposed to P. aeurigonsa: Colonized vs Non colonized animals

ABSTRACT: Transcriptional profiling of adult C.elegans exposed to E.coli or to GFP-expressing P. aeruginosa (strain PA14). For P. aeruginosa exposure, worms were separated into 2 groups - fully colonized (green) or non-colonized (dark). Three conditions (E.coli, P. aeurginosa colonized, and P. aeurginosa non-colonized). 2-color arrrays, each sample co-hybridized with the same reference RNA sample from mixed stage C.elegans cultures Each condition includes 3 biological replicates - 2 using the wormsorter (WS) to separate colonized from non-colonized and one hand picked (HP) under a fluorescent stereoscope

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Michael Shapira 

PROVIDER: E-GEOD-39536 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dissociation of immune responses from pathogen colonization supports pattern recognition in C. elegans.

Twumasi-Boateng Kwame K   Shapira Michael M  

PloS one 20120413 4

Caenorhabditis elegans has been used for over a decade to characterize signaling cascades controlling innate immune responses. However, what initiates these responses in the worm has remained elusive. To gain a better understanding of the initiating events we delineated genome-wide immune responses to the bacterial pathogen Pseudomonas aeruginosa in worms heavily-colonized by the pathogen versus worms visibly not colonized. We found that infection responses in both groups were identical, suggest  ...[more]

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