Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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FMR1 targets distinct mRNA sequence elements to regulate protein expression


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Manuel Ascano 

PROVIDER: E-GEOD-39686 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism in males and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASDs). FXS is typically caused by the loss of fragile X mental retardation 1 (FMR1) expression, which codes for the RNA-binding protein FMRP. Here we report the discovery of distinct RNA-recognition elements that correspond to the two independent RNA  ...[more]

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