Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Uma Shankavaram
PROVIDER: E-GEOD-39716 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Neoplasia (New York, N.Y.) 20130401 4
Pheochromocytomas (PHEOs) and paragangliomas (PGLs) related to mutations in the mitochondrial succinate dehydrogenase (SDH) subunits A, B, C, and D, SDH complex assembly factor 2, and the von Hippel-Lindau (VHL) genes share a pseudohypoxic expression profile. However, genotype-specific differences in expression have been emerging. Development of effective new therapies for distinctive manifestations, e.g., a high rate of malignancy in SDHB- or predisposition to multifocal PGLs in SDHD patients, ...[more]