Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Balazs Györffy
PROVIDER: E-GEOD-39857 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Győrffy Balázs B Stelniec-Klotz Iwona I Sigler Christian C Kasack Katharina K Redmer Torben T Qian Yu Y Schäfer Reinhold R
Oncotarget 20150501 15
Our understanding of oncogenic signaling pathways has strongly fostered current concepts for targeted therapies in metastatic colorectal cancer. The RALA pathway is novel candidate due to its independent role in controlling expression of genes downstream of RAS.We compared RALA GTPase activities in three colorectal cancer cell lines by GTPase pull-down assay and analyzed the transcriptional and phenotypic effects of transient RALA silencing. Knocking-down RALA expression strongly diminished the ...[more]