Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Gene Yeo
PROVIDER: E-GEOD-39873 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wilbert Melissa L ML Huelga Stephanie C SC Kapeli Katannya K Stark Thomas J TJ Liang Tiffany Y TY Chen Stella X SX Yan Bernice Y BY Nathanson Jason L JL Hutt Kasey R KR Lovci Michael T MT Kazan Hilal H Vu Anthony Q AQ Massirer Katlin B KB Morris Quaid Q Hoon Shawn S Yeo Gene W GW
Molecular cell 20120906 2
LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, but here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) targets. Through crosslinking and immunoprecipitation coupled with high-throughput sequencing (CLIP-seq) in human embryonic stem cells and somatic cells expressing exogenous LIN28, we have defined discrete LIN28-bindin ...[more]