Unknown,Transcriptomics,Genomics,Proteomics

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LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE39855: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array) GSE39872: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Gene Yeo 

PROVIDER: E-GEOD-39873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, but here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) targets. Through crosslinking and immunoprecipitation coupled with high-throughput sequencing (CLIP-seq) in human embryonic stem cells and somatic cells expressing exogenous LIN28, we have defined discrete LIN28-bindin  ...[more]

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