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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of human monocytes and monocyte-derived macrophages

ABSTRACT: microRNA profiling data includes biological replicates of primary monocytes and macrophages from three human donors Dye swap hybridization arrays were performed for total RNA isolated from fresh monocytes and 7-day monocyte-derived macrophages from each of three human donors

ORGANISM(S): Homo sapiens

SUBMITTER: Kenneth Witwer

PROVIDER: E-GEOD-39905 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miRNA profiles of monocyte-lineage cells are consistent with complicated roles in HIV-1 restriction.

Sisk Jeanne M JM Clements Janice E JE Witwer Kenneth W KW

Viruses 20120925 10

Long-lived HIV-1 reservoirs include tissue macrophages. Monocyte-derived macrophages are more susceptible to infection and more permissive to HIV-1 replication than monocytes for reasons that may include the effects of different populations of miRNAs in these two cell classes. Specifically, miRs-28-3p, -150, -223, -198, and -382 exert direct or indirect negative effects on HIV-1 and are reportedly downmodulated during monocyte-to-macrophage differentiation. Here, new experimental results are pre ...[more]

PMID: 23202444

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2011-07-24 | E-GEOD-30811 | biostudies-arrayexpress

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