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Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses [Expt: Geni_Bafi]

ABSTRACT: Within the overall project, we performed a set of microarray and chromatin-immunoprecipitation (ChIP)-chip experiments using siRNA against the (pro)renin receptor ((P)RR), stable overexpression of PLZF, the PLZF translocation inhibitor genistein and the specific V-ATPase inhibitor bafilomycin to dissect transcriptional pathways downstream of the (P)RR. In this dataset, we include the expression data obtained from KELLY cells incubated with genistein or bafilomycin A1. Five intervention samples and three control samples were analyzed. We generated the following pairwise comparisons using Chipinspector (Genomatix Software GmbH) and a FDR of 0.5% (bafilomycin), 5% (genistein): genistein- versus DMSO- and bafilomycin- versus DMSO-treated cells. ChipInspector carries out significance analysis on the single probe level. Normalized probe set level data not provided for individual Sample records. Processed data is available on Series record.

ORGANISM(S): Homo sapiens

SUBMITTER: Daniela Zaade 

PROVIDER: E-GEOD-39962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses.

Zaade Daniela D   Schmitz Jennifer J   Benke Eileen E   Klare Sabrina S   Seidel Kerstin K   Kirsch Sebastian S   Goldin-Lang Petra P   Zollmann Frank S FS   Unger Thomas T   Funke-Kaiser Heiko H  

PloS one 20130304 3

The (pro)renin receptor ((P)RR) signaling is involved in different pathophysiologies ranging from cardiorenal end-organ damage via diabetic retinopathy to tumorigenesis. We have previously shown that the transcription factor promyelocytic leukemia zinc finger (PLZF) is an adaptor protein of the (P)RR. Furthermore, recent publications suggest that major functions of the (P)RR are mediated ligand-independently by its transmembrane and intracellular part, which acts as an accessory protein of V-ATP  ...[more]

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