Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: WeiPing Chen
PROVIDER: E-GEOD-39989 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Scientific reports 20151119
Loss of olfactomedin 4 (OLFM4) gene expression is associated with the progression of human prostate cancer, but its role and the molecular mechanisms involved in this process have not been completely understood. In this study, we found that Olfm4-knockout mice developed prostatic intraepithelial neoplasia and prostatic adenocarcinoma. Importantly, we found that the hedgehog-signaling pathway was significantly upregulated in the Olfm4-knockout mouse model. We also found that restoration of OLFM4 ...[more]