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Mutation Mapping of 40 Streptococcus suis strains

ABSTRACT: Streptococcus suis is an important zoonotic pathogen that can cause meningitis and sepsis in both pigs and humans. In this study,we evaluated the genetic difference of 40 Streptococcus suis strains belonging to various sequence types by comparative genomic hybridization to identify genes associated with the variation in pathogenicity using NimbleGenM-bM-^@M-^Ys tilling microarray platform. Application of Comparative Phylogenomics to Identify Genetic Differences Relating to Pathogenicity of Streptococcus suis Comparative genomic analysis on the 40 S.suis strains of different serotypes and ST types through tilling arrays

ORGANISM(S): Streptococcus suis

SUBMITTER: Xiao Zheng

PROVIDER: E-GEOD-40035 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparative genomic hybridization identifies virulence differences in Streptococcus suis.

Zheng Han H Lan Ruiting R Zheng Xiao X Cui Zhigang Z Liu Zhijie Z Bai Xuemei X Ji Shaobo S Gottschalk Marcelo M Xu Jianguo J

PloS one 20140204 2

Streptococcus suis is an important zoonotic pathogen. However, identification of virulent S. suis strains is complicated because of the high diversity of the species. Here we evaluated the genetic difference among S. suis strains using comparative genomic hybridization (CGH) and virulence variation in vivo and in vitro. We showed that different clades differed in their ability to activate TLR2/6 in vitro and their capacity to induce cytokine production in vivo as well as their resistance to phag ...[more]

PMID: 24503649

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