Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Bcl6 expression specifies the T follicular helper cell program in vivo


ABSTRACT: T follicular helper (Tfh) cells play a pivotal role in germinal center reactions, which requires Bcl6 transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage reporter systems. Assisted with genome-wide transcriptome analysis, we show substantial plasticity of T cell differentiation in the early phase of immune response. At this stage, CXCR5 appears to be expressed in a Bcl6-independent manner. Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program. Three group of samples, with 2 biological replicates within each group and total of 6 samples were analyzed.

ORGANISM(S): Mus musculus

SUBMITTER: Lai Wei 

PROVIDER: E-GEOD-40068 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2014-01-01 | E-GEOD-52839 | biostudies-arrayexpress
2014-01-01 | E-GEOD-52840 | biostudies-arrayexpress
2011-06-02 | E-GEOD-24574 | biostudies-arrayexpress
2012-09-17 | GSE40068 | GEO
2015-03-01 | E-GEOD-66373 | biostudies-arrayexpress
2021-03-19 | PXD008563 | Pride
2023-07-31 | E-MTAB-12085 | biostudies-arrayexpress
2010-02-17 | E-MEXP-2062 | biostudies-arrayexpress
2014-10-27 | E-GEOD-58596 | biostudies-arrayexpress
2014-09-14 | E-GEOD-58365 | biostudies-arrayexpress