Unknown,Transcriptomics,Genomics,Proteomics

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PLA2G2A and human gastric cancers


ABSTRACT: We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set Using regression correlation

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Chen 

PROVIDER: E-GEOD-4007 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer.

Leung Suet Yi SY   Yuen Siu Tsan ST   Chu Kent-Man KM   Mathy Jonathan A JA   Li Rui R   Chan Annie S Y AS   Law Simon S   Wong John J   Chen Xin X   So Samuel S  

Gastroenterology 20040801 2


<h4>Background & aims</h4>Gastric cancer is one of the major cancers worldwide. Expression profiling has proven useful in delineating novel prognostic markers in various cancer types. We previously analyzed gene-expression patterns in 90 gastric adenocarcinomas by using complementary DNA microarrays and prioritized a list of genes whose expression levels predict patient outcome.<h4>Methods</h4>We identified a specific gene of interest, chemokine (C-C motif) ligand 18 (CCL18), on the basis of a h  ...[more]

Publication: 1/2

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