Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Charles Reay Mackay
PROVIDER: E-GEOD-4014 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jeffrey Kate L KL Brummer Tilman T Rolph Michael S MS Liu Sue M SM Callejas Nuria A NA Grumont Raelene J RJ Gillieron Corine C Mackay Fabienne F Grey Shane S Camps Montserrat M Rommel Christian C Gerondakis Steve D SD Mackay Charles R CR
Nature immunology 20060212 3
Mitogen-activated protein kinases facilitate many cellular processes and are essential for immune cell function. Their activity is controlled by kinases and dual-specificity phosphatases. A comprehensive microarray analysis of human leukocytes identified DUSP2 (encoding the phosphatase PAC-1) as one of the most highly induced transcripts in activated immune cells. We generated Dusp2(-/-) mice and found considerably reduced inflammatory responses in the 'K/BxN' model of rheumatoid arthritis. PAC- ...[more]