Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of mouse macrophaes and mast cells from Pac1+/+ versus Pac1-/- animals


ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE3993: Pac1+/+ versus Pac1-/- TG-macrophages_LPS 6h; GSE3994: Pac1+/+ versus Pac1-/- BMMCs_IgE-DNP 2 h Experiment Overall Design: Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Charles Reay Mackay 

PROVIDER: E-GEOD-4014 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Mitogen-activated protein kinases facilitate many cellular processes and are essential for immune cell function. Their activity is controlled by kinases and dual-specificity phosphatases. A comprehensive microarray analysis of human leukocytes identified DUSP2 (encoding the phosphatase PAC-1) as one of the most highly induced transcripts in activated immune cells. We generated Dusp2(-/-) mice and found considerably reduced inflammatory responses in the 'K/BxN' model of rheumatoid arthritis. PAC-  ...[more]

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