The blood transcriptional signature of chronic HCV [Affymetrix data]

ABSTRACT: This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identified a 136 gene signature, including 66 genes elevated in infected individuals. Most of the up-regulated genes were associated with interferon (IFN) activity (including members of the OAS and MX families, ISG15 and IRF7), suggesting an ongoing immune response. This HCV signature was also found to be consistently enriched in many other viral infection and vaccination datasets. Validation of these genes was carried out using a second cohort composed of 5 HCV patients and 5 healthy volunteers, confirm

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Bolen 

PROVIDER: E-GEOD-40184 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress