Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Olivier Elemento
PROVIDER: E-GEOD-40291 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ginsberg Michael M James Daylon D Ding Bi-Sen BS Nolan Daniel D Geng Fuqiang F Butler Jason M JM Schachterle William W Pulijaal Venkat R VR Mathew Susan S Chasen Stephen T ST Xiang Jenny J Rosenwaks Zev Z Shido Koji K Elemento Olivier O Rabbany Sina Y SY Rafii Shahin S
Cell 20121018 3
ETS transcription factors ETV2, FLI1, and ERG1 specify pluripotent stem cells into induced vascular endothelial cells (iVECs). However, iVECs are unstable and drift toward nonvascular cells. We show that human midgestation c-Kit(-) lineage-committed amniotic cells (ACs) can be reprogrammed into vascular endothelial cells (rAC-VECs) without transitioning through a pluripotent state. Transient ETV2 expression in ACs generates immature rAC-VECs, whereas coexpression with FLI1/ERG1 endows rAC-VECs w ...[more]