Effect of Chlorpromazine HCl on Rat Primary Hepatocytes.

ABSTRACT: This study provides an evaluation of changes in gene expression associated with chlorpromazine HCl treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (0.8 uM and 20 uM) of chlorpromazine HCl and 1% DMSO vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis. This series is part of a SuperSeries in which primary rat hepatocytes were treated with two doses of ten chemical compounds (and corresponding vehicle controls) for 24 and 48 hours. Each compound/vehicle treatment group was an individual study performed at different times. Each study was analyzed separately and themes common between studies were reported. Time Course/Dose Response

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jay Tiesman 

PROVIDER: E-GEOD-40341 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress