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The effects of NAC on gene expression in Nkx3.1-/- mouse prostate

ABSTRACT: We tested the effects of the antioxidant NAC (N-Acetyl-Cysteine) on gene expression in Nkx3.1-deficient mouse prostate. Mice that were homozygous null for Nkx3.1 were given NAC or plain water ad libidum for 13 weeks after weaning. Prostates were collected, RNA was harvested and reverse transcribed, and cDNA was hybridized to Affy Mouse Gene 1.0 ST microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Philip Anderson

PROVIDER: E-GEOD-40352 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Antioxidant treatment promotes prostate epithelial proliferation in Nkx3.1 mutant mice.

Martinez Erin E EE Anderson Philip D PD Logan Monica M Abdulkadir Sarki A SA

PloS one 20121015 10

Discordant results in preclinical and clinical trials have raised questions over the effectiveness of antioxidants in prostate cancer chemoprevention. Results from the large-scale Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed that antioxidants failed to prevent, and in some cases promoted, prostate cancer formation in men without a history of the disease. One possible explanation for these alarming results is the notion that the effects of antioxidant treatment on the prostate a ...[more]

PMID: 23077524

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