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Lack of local vitamin D synthesis accelerates breast cancer development after Cyp27B1 gene ablation in mammary epithelium

ABSTRACT: The ablated Cyp27b1 mice showed no difference in mammary development but tumorigenesis was significantly accelerated. Cell proliferation, angiogenesis, cell cycle progression and survival markers were upregulated by Cyp27b1 ablation, a pattern confirmed by microarray analysis. Triplicate samples each of control mice and Cyp27b1 knockout mice.

ORGANISM(S): Mus musculus

SUBMITTER: greg VOISIN

PROVIDER: E-GEOD-40375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Lack of local vitamin D synthesis accelerates breast cancer development after Cyp27B1 gene ablation in mammary epithelium

Project description:The ablated Cyp27b1 mice showed no difference in mammary development but tumorigenesis was significantly accelerated. Cell proliferation, angiogenesis, cell cycle progression and survival markers were upregulated by Cyp27b1 ablation, a pattern confirmed by microarray analysis.

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2012-04-17 | E-GEOD-37331 | biostudies-arrayexpress

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CD40-mediated amplification of local immunity by keratinocytes in impaired by HPV

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