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Expression profiling of human primary breast cancer tissue before treatment with gemcitabine, epirubicine and docetaxel

ABSTRACT: Gene expression profiles of human breast cancer tissues from 100 different patients treated with primary systemic chemotherapy (Gemcitabine, Epirubicin and Docetaxel) Keywords: expression profiling Human breast cancer tissues from 100 patients have been used to perform expression profiling analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Olaf Thuerigen

PROVIDER: E-GEOD-4056 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer.

Thuerigen Olaf O Schneeweiss Andreas A Toedt Grischa G Warnat Patrick P Hahn Meinhard M Kramer Heidi H Brors Benedikt B Rudlowski Christian C Benner Axel A Schuetz Florian F Tews Bjoern B Eils Roland R Sinn Hans-Peter HP Sohn Christof C Lichter Peter P

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060401 12

<h4>Purpose</h4>Primary systemic therapy (PST) with gemcitabine (G), epirubicin (E), and docetaxel (Doc) has resulted in a pathologic complete response (pCR) in 26% of primary breast cancer patients. This study was aimed at the identification of a gene expression signature in diagnostic core biopsy tissue samples that predicts pCR.<h4>Patients and methods</h4>Core biopsy samples from patients with operable primary breast cancer, T2-4N0-2M0, enrolled onto two phase I and II trials evaluating GEDo ...[more]

PMID: 16622258

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