Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells
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ABSTRACT:
ORGANISM(S): Drosophila simulans
SUBMITTER: SEVERINE CHAMBEYRON
PROVIDER: E-GEOD-40592 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells.
Akkouche Abdou A Grentzinger Thomas T Fablet Marie M Armenise Claudia C Burlet Nelly N Braman Virginie V Chambeyron Séverine S Vieira Cristina C
EMBO reports 20130405 5
Transposable elements (TEs), whose propagation can result in severe damage to the host genome, are silenced in the animal gonad by Piwi-interacting RNAs (piRNAs). piRNAs produced in the ovaries are deposited in the embryonic germline and initiate TE repression in the germline progeny. Whether the maternally transmitted piRNAs play a role in the silencing of somatic TEs is however unknown. Here we show that maternally transmitted piRNAs from the tirant retrotransposon in Drosophila are required f ...[more]
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