Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: LI SHEN
PROVIDER: E-GEOD-40613 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Menge Tyler T Zhao Yuhai Y Zhao Jing J Wataha Kathryn K Gerber Michael M Zhang Jianhu J Letourneau Phillip P Redell John J Shen Li L Wang Jing J Peng Zhalong Z Xue Hasen H Kozar Rosemary R Cox Charles S CS Khakoo Aarif Y AY Holcomb John B JB Dash Pramod K PK Pati Shibani S
Science translational medicine 20121101 161
Mesenchymal stem cells (MSCs) may be useful for treating a variety of disease states associated with vascular instability including traumatic brain injury (TBI). A soluble factor, tissue inhibitor of matrix metalloproteinase-3 (TIMP3), produced by MSCs is shown to recapitulate the beneficial effects of MSCs on endothelial function and to ameliorate the effects of a compromised blood-brain barrier (BBB) due to TBI. Intravenous administration of recombinant TIMP3 inhibited BBB permeability caused ...[more]