DNA Methylation Changes and Childhood Asthma in the Inner City [gene expression]

ABSTRACT: Background: Epigenetic marks, like asthma, are heritable. They are influenced by the environment, direct the maturation of T cellslymphocytes, and have been shown to enhance the development of allergic airways disease in mice. Thus, we hypothesized that epigenetic marks are associated with allergic asthma in inner-city children. Methods: We compared methylation patterns and gene expression in inner-city children with persistent atopic asthma versus healthy controls, using DNA and RNA from peripheral blood mononuclear cells (PBMCs) from inner city children aged 6-12 years with persistent atopic asthma children and healthy controls. Results were externally validated with the GABRIELA study population. Results: Comparing asthmatics (N=97) to controls (N=97), we identified 81 regio

ORGANISM(S): Homo sapiens

SUBMITTER: David Schwartz 

PROVIDER: E-GEOD-40732 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress