Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Chi Dang
PROVIDER: E-GEOD-4086 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kim Jung-whan JW Tchernyshyov Irina I Semenza Gregg L GL Dang Chi V CV
Cell metabolism 20060301 3
Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia through increased conversion of glucose to pyruvate and subsequently to lactate. We found that HIF-1 also actively suppresses metabolism through the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. Forced PDK1 expression in ...[more]