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Genome-wide analysis of white adipose tissue gene expression induced by maternal diet

ABSTRACT: The aim of this study is to characterize transcriptional changes induced by maternal diet in several adult tissues and to test whether differences in DNA methylation or microRNA expression could explain these changes. -------------------------- Note: non-normalized values and associated raw data cannot be located by the submitter Total RNA from offspring of mothers fed high fat or low fat diets

ORGANISM(S): Mus musculus

SUBMITTER: James Hester

PROVIDER: E-GEOD-40902 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide analysis of liver gene expression induced by maternal diet

Project description:The aim of this study is to characterize transcriptional changes induced by maternal diet in several adult tissues and to test whether differences in DNA methylation or microRNA expression could explain these changes. -------------------------- Note: non-normalized values and associated raw data cannot be located by the submitter Total RNA from offspring of mothers fed high fat or low fat diets

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Genome-wide analysis of white adipose tissue gene expression induced by maternal diet

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Genome-wide analysis of expression in various tissues in response to maternal diet

Project description:Note: non-normalized values and associated raw data cannot be located by the submitter This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-03-04 | E-GEOD-40903 | biostudies-arrayexpress

Genome-wide analysis of expression in various tissues in response to maternal diet

Project description:Note: non-normalized values and associated raw data cannot be located by the submitter This SuperSeries is composed of the SubSeries listed below.

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Are you also what Your Mother Eats? Distinct Proteomic Portrait as a Result of Maternal High-Fat Diet in the Cerebral Cortex of the Adult Mouse.

Project description:Background: Epidemiological studies suggest an association between maternal obesity and adverse neurodevelopmental outcomes in offspring. Objective: To compare the global proteomic portrait in the cerebral cortex between mice born to mothers on a high-fat or control diet who themselves were fed a high-fat or control diet. Methods: Male mice born to dams fed a control (C) or high fat (H) diet four weeks before conception and during gestation and lactation were assigned to either C or H diet at weaning. Mice (n=24) were sacrificed at 19-weeks and their cerebral cortices were pooled into 8 samples and analysed using an iTRAQ based 2D LC-MS methodology. Results: A total of 6,695 proteins were identified and fully quantified (q<0.01). Approximately 10% of these proteins demonstrated a minimum of one Standard Deviation of regulation across all biological replicates in at least one of the experimental groups (CH, HC, HH) relative to the control (CC). Principal component analysis and hierarchical clustering analysis showed that mice clustered based on the diet of the mother and not their current diet. In silico bioinformatics analysis revealed that maternal high-fat diet was significantly associated with response to hypoxia/oxidative stress and apoptosis in the cerebral cortex of the adult offspring. Conclusion: Maternal high-fat diet was associated with distinct endophenotypic changes of the adult mouse cerebral cortex independent of the diet of the offspring. The identified modulated proteins could represent novel therapeutic targets for the prevention of neuropathological features resulting from maternal obesity.

2018-01-29 | PXD001540 | Pride

Identification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity

Project description:Maternal obesity programs the offspring to cardiovascular disease, insulin resistance, and obesity. We sequenced and profiled the cardiac miRNAs that were dysregulated in the hearts of baboon fetuses born to a high fat / high fructose diet fed mothers compared to a regular diet fed mothers.

2013-02-01 | GSE43323 | GEO

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