Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of mRNA expression alterations of mucosa associated lymphoid tissue lymphoma translocation gene 1 (Malt1) -/- or Wild Type (WT) Naïve T cells induced to differentiate into (T helper) Th1 or Th17 cells


ABSTRACT: Microarrays were used to examine gene expression changes at two time points following the induction of differentiation of Malt1 deficient Naive T cells into Th1 or Th17 cells. The present study aims to find the effect that Malt1 deficiency has on lineage specific T cell differentiation. Malt1 is a NF kappa B regulator and plays a key role in peripheral T cell activation and proliferation, but its role in T cell differentiation is not clear. Aspects of the latter are what the current data set investigates. Total RNA obtained from naïve T cells at two time points following induction to lineage specific T helper cells.

ORGANISM(S): Mus musculus

SUBMITTER: carl virtanen 

PROVIDER: E-GEOD-40931 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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