Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

The Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer


ABSTRACT: Poor outcomes in diabetic patients are observed across a range of human tumors, suggesting that cancer cells develop unique characteristics under diabetic conditions. Cancer cells exposed to hyperglycemic insults acquire permanent aggressive traits of tumor growth, even after a return to euglycemic conditions. Comparative genome-wide mapping of hyperglycemia-specific open chromatin regions and concomitant mRNA expression profiling revealed that neuregulin-1 gene, an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes Chromatin was extracted from hyperglycemic (HyG) and euglycemic (Control) cancer cells; FAIRE DNA and input DNA from each sample were used to generate libraries for single end sequencing on the the SOLiD 4 HQ system

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Person 

PROVIDER: E-GEOD-40949 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2012-09-19 | GSE40949 | GEO
2017-02-01 | GSE87433 | GEO
2013-08-01 | E-GEOD-44221 | biostudies-arrayexpress
2016-07-14 | E-GEOD-75770 | biostudies-arrayexpress
2015-04-08 | E-GEOD-54971 | biostudies-arrayexpress
2013-08-01 | E-GEOD-44224 | biostudies-arrayexpress
2014-06-01 | E-GEOD-57237 | biostudies-arrayexpress
2014-06-24 | E-MTAB-2283 | biostudies-arrayexpress
2011-01-04 | E-GEOD-23701 | biostudies-arrayexpress
2014-06-01 | GSE57237 | GEO